Valvular & structural heart diseaseCohort study
Hypoattenuated Leaflet Thickening and Reduced Leaflet Motion After Transcatheter Tricuspid Valve Replacement
- Cohort study
Authors' conclusion
HALT and RLMCT are common after TTVR and are associated with elevated gradients and reduced symptomatic alleviation. Transthoracic echocardiography is insensitive for detecting HALT and RLM
Study context
- Population
- Patients undergoing orthotopic transcatheter tricuspid valve replacement (TTVR)45 with 30-day computed tomographic (CT)
- Participants
- 53 patients
Main finding
As reported in the abstract
HALT and RLM on 30-day CT · 30 days
- Moderate to severe hypoattenuated leaflet thickening (HALT)
- 12 (27%)
- RLMCT none
- 15 (33%)
- RLMCT mild to moderate
- 21 (74%)
- RLMCT severe
- 9 (20%)
- HALT correlated with RLMCT severity
- P < 0.001
- HALT and RLMCT associated with increased transvalvular gradient
- P = 0.032 and P < 0.0001
- HALT and RLMCT associated with reduced NYHA class improvement at 30 days
- P = 0.002 and P = 0.003
Observational data: associations, not effects.
Further findings
Echocardiographic detection
- RLMCT correlated with RLMecho
- P < 0.0001
- Severe reduced leaflet motion (RLM) detected by RLMecho
- 6 of 9
- Severe HALT detected on echocardiography
- 3 of 7
Anticoagulation strategy
- No association between HALT or RLMCT and anticoagulation strategy
Original publication
Hypoattenuated Leaflet Thickening and Reduced Leaflet Motion After Transcatheter Tricuspid Valve Replacement. JACC Cardiovasc Interv. Published 25 October 2025. doi:10.1016/j.jcin.2025.10.026
Summarised from the published abstract; every number is checked against it