Valvular & structural heart disease
Indexed Aortic Valve Calcium Volume by Computed Tomography Angiography in Patients With Aortic Stenosis: Results of an International Multicenter Cohort Study
Authors' conclusion
In patients with aortic stenosis, indexed aortic valve calcium volume from CTA provides accurate discrimination of disease severity and additive prognostic information.
Study context
- Population
- Patients with mild to severe AS with concurrent computed tomography angiography (CTA) and echocardiographyderivation 689, validation 459
- Participants
- 1,521 patients
- Exposure
- Indexed aortic valve calcium volume by CTA for AS severity and prognosis
- Outcome
- Diagnosis of severe AS (derivation cohort)
Methodological detailsinternational, multicentre, observational
- International
- Multicentre
- Observational
Main finding
As reported in the abstract
| Strategy | C-statistic |
|---|---|
| Men | 0.900 |
| Women | 0.926 |
C-statistic
Observational data: associations, not effects.
Further findings
AVR or all-cause mortality by indexed calcium volume thresholds
| HR (95% CI) | P value | ||
|---|---|---|---|
| Indexed calcium volume thresholdsWhole cohort; independently associated | 2.01 (1.30–3.10) | P < 0.01 | |
| Indexed calcium volume thresholdsDiscordant echocardiography | 1.58 (1.01–2.44) | ||
| 0.20.5125Hazard ratio (log scale) |
- AVR or all-cause mortality by indexed calcium volume thresholds: outcomes available in 711 patients
Correlation of indexed AV calcium volume with peak aortic jet velocity and noncontrast computed tomography (CT) calcium score
- Correlation with peak aortic jet velocity (ρ)
- 0.723; P < 0.001
- Correlation with noncontrast CT calcium score (ρ)
- 0.896; P < 0.001
Diagnostic discrimination for severe AS by sex-specific indexed calcium volume thresholds (men: 122 mm³/cm²; women: 61 mm³/cm²)
- C-statistic, men, derivation cohort (n = 689)
- 0.900
- C-statistic, women, derivation cohort (n = 689)
- 0.926
- C-statistic, men, validation cohort (n = 459)
- 0.933
- C-statistic, women, validation cohort (n = 459)
- 0.944
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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