Heart failure & cardiomyopathies
Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size
Authors' conclusion
In a clinical population, we identified, by genomic approaches, potential etiologic risk factors for larger LAD.
Study context
- Population
- Adults of European ancestry in the Vanderbilt deidentified electronic health record with ≥1 left atrial diameter (LAD) measure and genotyping
- Participants
- 6,163 vs 5,993
- Exposure
- Females vs Males
- Femalesn = 6,163
- Malesn = 5,993
- Outcome
- Diagnoses (1680 ICD code-based phenotypes) associated with a sex-stratified polygenic score for LAD, and etiologic risk factors for LAD by Mendelian randomization
Methodological detailsphenome-wide association study and Mendelian randomization, sex-stratified, polygenic score, two-sample univariable and multivariable Mendelian randomization, EHR-based clinical cohort
- Phenome-wide association study and Mendelian randomization
- Sex-stratified
- Polygenic score
- Two-sample univariable and multivariable Mendelian randomization
- EHR-based clinical cohort
Main finding
As reported in the abstract
ICD code-based diagnoses associated with LAD polygenic score (FDR q<0.01)
| Group | Associated diagnoses |
|---|---|
| Females | 25 |
| Males | 11 |
Associated diagnoses
Females25
Males11
Observational data: associations, not effects.
Further findings
Sex-stratified genetic associations between risk factors and LAD polygenic score
- Females: waist circumference
- Males: HF, SBP, AF and waist circumference
Original publication
Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size. Circ Heart Fail. Published 21 December 2023. doi:10.
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