Pulmonary vascular disease & thromboembolism
Identification of Serum C4BPA as a Potential Diagnostic Marker of Right Ventricular Remodelling Via Proteomic Analysis
Authors' conclusion
Serum C4BPA may represent a novel diagnostic biomarker for RV pathological remodelling associated with RV maladaptation in PH patients.
Study context
- Population
- Rats with sham surgery or pulmonary artery banding inducing mild or severe right ventricular (RV) remodelling; patients with RV pressure overload, left ventricular hypertrophy and controlspatients in the validation cohort · adaptive RV pressure overload 34 · maladaptive RV pressure overload 36 · left ventricular hypertrophy 32 · controls 25
- Participants
- 127 rats
- Index test or model
- Serum C4BPA vs BNP for maladaptive RV function in PH patients
- Target condition
- maladaptive RV function in PH patients
Methodological detailsSprague-Dawley rat pulmonary artery banding model, high-throughput proteomic analysis
- Sprague-Dawley rat pulmonary artery banding model
- High-throughput proteomic analysis
Performance
As reported in the abstract
Cut-off value
573 pg/mL
Area under the curve
0.792
Further findings
Serum C4BPA levels in patients
| Outcome | Beta (95% CI) | P value |
|---|---|---|
| Serum C4BPA and TAPSE in rats (linear regression)Negative correlation with TAPSE | −0.78 (−14.5 to −7.11) | P < 0.001 |
- Serum C4BPA levels in patients: P < 0.001
Serum proteomic profiling in rats
- Differentially expressed serum proteins (DEPs) among the three groups
- 170
- DEPs gradually increasing with worsening RV remodelling
- three
Serum C4BPA in rats, severe group
- Highest upregulation in the severe group
- 6.93 vs. 16.5 ng/mL, P < 0.001
Serum C4BPA levels in patients
- Control and left ventricular hypertrophy patients exhibited lower serum C4BPA levels than the two RV groups
Serum C4BPA and tricuspid annular plane systolic excursion (TAPSE) in PH patients
- Negative correlation
High serum C4BPA (≥573 pg/mL): TAPSE/pulmonary arterial systolic pressure ratio and BNP
- Lower TAPSE/pulmonary arterial systolic pressure ratios
- P < 0.001
- Higher BNP levels
- P < 0.001
Original publication
Identification of Serum C4BPA as a Potential Diagnostic Marker of Right Ventricular Remodelling Via Proteomic Analysis. ESC Heart Fail. Published 16 April 2025. doi:10.
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