Heart failure & cardiomyopathies
IL-17 is Associated with Disease Severity and Targetable Inflammatory Processes in Heart Failure
Authors' conclusion
In patients with HF, elevated IL-17 concentrations indicate more severe HF and increased activity of inflammatory processes known to be involved in the pathophysiology of HF.
Study context
- Population
- Patients diagnosed with heart failure (HF)validation cohort n = 1737
- Participants
- 2,082 patients
- Exposure
- High vs low circulating IL-17 concentrations
- Outcome
- Clinical characteristics, outcomes and pathways associated with IL-17
Methodological detailsindependent validation cohort, IL-17 measured by ELISA; 363 circulating proteins by proximity extension assay
- Independent validation cohort
- IL-17 measured by ELISA; 363 circulating proteins by proximity extension assay
Main finding
As reported in the abstract
- Elevated IL-17: more severe HF (more current or previous HF hospitalizations, higher NYHA class, higher NT-proBNP)
- High IL-17 independently associated with increased risk of HF hospitalization and mortality
- Most up-regulated proteins with high IL-17 (both cohorts): FGF-21, IL-6, CXCL13, TNFRSF6B, IL-1RA
- Increased activity of pathways of lymphocyte-mediated immunity, leukocyte activation and immune-response regulation
Observational data: associations, not effects.
Original publication
IL-17 is Associated with Disease Severity and Targetable Inflammatory Processes in Heart Failure. ESC Heart Fail. Published 19 July 2024. doi:10.
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