Immature Surfactant Protein Type-B Associates With Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting
Authors' conclusion
Elevated preoperative proSP-B is independently associated with 18-month graft occlusion following CABG.
Study context
- Population
- Patients undergoing coronary artery bypass graft (CABG)
- Participants
- 40 vs 130
- Comparison
- Graft occlusion vs no occlusion
- Casesn = 40
- Noncasesn = 130reference
- Outcome
- Graft occlusion (coronary CT angiography and/or invasive angiography) in relation to preoperative plasma proSP-B
- Follow-up
- 18 months post-CABG
Main finding
As reported in the abstract
Preoperative proSP-B
P = 0.002
Observational data: associations, not effects.
Further findings
Predictive performance of adding proSP-B to a reference model
- AUC, reference model
- 0.7204
- AUC, with proSP-B
- 0.7733
- Net reclassification improvement (SE 0.18)
- 0.43
- NRI P = 0.02
Original publication
Immature Surfactant Protein Type-B Associates With Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting. JACC Adv. Published 3 September 2025. doi:10.
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