Representation of Older Adults and Women in Randomized Trials of Noninvasive Imaging for Chest Pain
Authors' conclusion
Although women were appropriately represented, adults ≥65 years, especially those ≥75 years, were underrepresented in these trials.
Study context
- Population
- RCTs of noninvasive imaging-guided diagnosis and management for ischemic heart disease (acute and stable chest pain), published 2002–202353 RCTs
- Comparison
- <65 years vs 65 to 74 years vs ≥75 years vs Women
- Outcome
- Participation-to-prevalence ratio (PPR) by age subgroup and for women (<0.8 underrepresentation, 0.8 to 1.2 appropriate, >1.2 overrepresentation)
Methodological detailsSystematic search of PubMed, ClinicalTrials.gov and guidelines
- Systematic search of PubMed, ClinicalTrials.gov and guidelines
Pooled result
As reported in the abstract
PPR
<65 years
2.13
median · IQR 1.73–2.43
65 to 74 years
0.74
median · IQR 0.56–0.83
≥75 years
0.21
median · IQR 0.11–0.33
Women
1.2
median · IQR 1.06–1.32
Further pooled results
Age across all trials
- Median age 57.4 years (IQR 55.0-60.2)
Original publication
Representation of Older Adults and Women in Randomized Trials of Noninvasive Imaging for Chest Pain. Circ Cardiovasc Imaging. Published 3 September 2025. doi:10.
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