Immediate or staged complete revascularisation in patients presenting with acute coronary syndrome by number of diseased vessels: a substudy of the BIOVASC randomised trial
Authors' conclusion
ICR might be an option in patients presenting with extensive 3VD and might be associated with a lower rate of myocardial infarction compared with SCR.
Study context
- Population
- Patients presenting with acute coronary syndrome (ACS) and two-vessel (2VD) or three-vessel disease (3VD)1,177 2VD
- Participants
- 1,525 patients
- Comparison
- Immediate complete revascularisation (ICR) vs staged complete revascularisation (SCR), by number of diseased vessels
- Primary endpoint
- All-cause mortality, MI, any unplanned ischaemia-driven revascularisation or cerebrovascular events
- Follow-up
- 1 year after the index procedure
Methodological detailsprespecified analysis, Comparisons by Cox regression
- Prespecified analysis
- Comparisons by Cox regression
Primary result
As reported in the abstract
Primary endpoint by number of diseased vessels (subgroups) · 1 year
ICR vs SCRHazard ratio (95% CI)P value
2VD (ICR 613 vs SCR 564)
0.76(0.50–1.13)
P = 0.183VD (ICR 117 vs SCR 148)
0.79(0.39–1.59)
P = 0.51Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MI in 3VD (subgroup) | 0.21 (0.046–0.93) | P = 0.04 | |
| 0.050.21520Hazard ratio (log scale) |
- Myocardial infarction (MI) in 3VD (subgroup): interaction P=0.30
Original publication
Immediate or staged complete revascularisation in patients presenting with acute coronary syndrome by number of diseased vessels: a substudy of the BIOVASC randomised trial. EuroIntervention. Published 15 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it