Valvular & structural heart disease
Relation of Residual Mitral Regurgitation and Gradient Following Mitral Valve Transcatheter Edge-to-Edge Repair
Authors' conclusion
Discharge rMR ≤1+ is independently associated with lower 1-year mortality after PASCAL mitral valve transcatheter edge-to-edge repair.
Study context
- Population
- Consecutive patients treated with PASCAL mitral valve transcatheter edge-to-edge repair (REPAIR registry)median follow-up 463 days
- Participants
- 2,172 patients
- Exposure
- Discharge residual mitral regurgitation (rMR) and mitral pressure gradient (MPG) categories after PASCAL mitral TEER
- Outcome
- Mortality
- Follow-up
- 1 year
Methodological detailsinvestigator-initiated, multicentre, consecutive patients
- Investigator-initiated
- Multicentre
- Consecutive patients
Main finding
As reported in the abstract
1-year mortality
Estimate (95% CI)P value
rMR ≤1+ vs rMR ≥2+independent of dichotomized or continuous MPG
HR 0.54(0.37–0.74)
P < 0.001MPG <5 vs ≥5 mm Hg (dichotomized) vs Optimalnot significant
HR 0.73(0.51–1.04)
P = 0.078Continuous MPG vs Optimal
HR per mm Hg increase 1.10(1.00–1.21)
P = 0.048Continuous MPG, adjusted for rMR ≤1+ vs Optimal
adjusted HR per mm Hg increase 1.07(0.98–1.18)
P = 0.145- 1-year mortality differed significantly across groups
- P < 0.001
- No interaction between rMR ≤1+ and dichotomized/continuous MPG
- both Pinteraction >0.450
Observational data: associations, not effects.
Original publication
Relation of Residual Mitral Regurgitation and Gradient Following Mitral Valve Transcatheter Edge-to-Edge Repair. Circ Cardiovasc Interv. Published 28 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it