Valvular & structural heart disease
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Authors' conclusion
On serial evaluation, older patients and women with chronic AR maintained smaller LV volumes than younger patients and men, respectively, and develop AE at lower LV volumes.
Study context
- Population
- Adults with severe aortic regurgitation (AR) serially monitored by echocardiogram, 2010–201626% women
- Participants
- 525 adults
- Exposure
- Left ventricular (LV) remodeling and adverse events (AE) by age and sex
- Outcome
- 1) LVESVi and LV end-diastolic volume indexed to BSA; 2) AE
Methodological detailsconsecutive patients, serial echocardiography
- Consecutive patients
- Serial echocardiography
Main finding
As reported in the abstract
Baseline LVESVi
Observational data: associations, not effects.
Further findings
- Optimal LVESVi threshold for AE, by age and sex — Women
- 27 mL/m²
- Optimal LVESVi threshold for AE, by age and sex: Young men 50 mL/m²
- Optimal LVESVi threshold for AE, by age and sex: Older men 35 mL/m²
AE during follow-up · median echocardiogram follow-up 2.0 years (IQR: 1.0-3.6 years)
- AE
- 210 (40%)
Original publication
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. J Am Coll Cardiol. Published 18 April 2023. doi:10.
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