Valvular & structural heart disease
Impact of age on aortic valve calcium progression and risk for aortic stenosis: multi-ethnic study of atherosclerosis
Authors' conclusion
AVC progression was significantly associated with baseline AVC burden and was similar for younger vs. older persons after accounting for baseline AVC. The presence of AVC was significantly associated with a higher long-term risk for moderate-severe AS among both younger and older participants.
Study context
- Population
- Participants without overt cardiovascular disease between ages 45 and 8452.9% women · aortic valve calcium (AVC) = 0 5,899 · AVC >0 911 · age <65 years 3,834 · age ≥65 years 2,979
- Participants
- 6,810 participants
- Comparison
- Younger vs older participants; AVC >0 vs AVC = 0
- <65n = 3,834
- ≥65n = 2,979
- Outcome
- Median AVC
- Follow-up
- Visit 1
Methodological detailsmultivariable adjusted Cox proportional hazards
- Multivariable adjusted Cox proportional hazards
Main finding
As reported in the abstract
Further findings
Median annualized AVC progression, baseline AVC 1-99 · no significant difference
P = 0.303
Median annualized AVC progression, baseline AVC ≥100 · no significant difference
P = 0.846
Incident moderate-severe aortic stenosis (AS) · median follow-up of 16 years
| HR (95% CI) | ||
|---|---|---|
| AVC >0Younger participants · multivariable adjusted | 13.37 (5.67–31.52) | |
| AVC >0Older participants · multivariable adjusted | 10.59 (6.77–16.56) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Impact of age on aortic valve calcium progression and risk for aortic stenosis: multi-ethnic study of atherosclerosis. Eur Heart J Cardiovasc Imaging. Published 23 September 2025. doi:10.
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