Valvular & structural heart diseaseCohort study
Left Atrial Strain Predicts Cardiac Outcomes in Moderate Aortic Stenosis
- retrospective cohort study
Authors' conclusion
LARS is a sensitive and independent prognostic marker in moderate AS, reflecting cardiac remodeling. Regular assessment of left atrial strain could enhance risk stratification and guide clinical management strategies in patients with moderate AS.
Study context
- Population
- Patients diagnosed with moderate aortic stenosis (AS) between 2008 and 2019patients diagnosed with moderate AS
- Participants
- 1,125 patients
- Exposure
- Left atrial reservoir strain (LARS) and other cardiac remodeling indices as predictors of adverse cardiac events
- Outcome
- Cardiac death
Main finding
As reported in the abstract
Adjusted hazard ratio
0.948 per 1% increase
P = 0.003
- Kaplan-Meier-estimated 5-year rate of cardiac mortality
- 16.7%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | P value |
|---|---|---|
| Composite of cardiac death or heart failure hospitalization (secondary outcome) | adjusted hazard ratio 0.940 per 1% increase | P < 0.001 |
| Cardiac outcomes after aortic valve replacement | hazard ratio 2.177 | P = 0.024 |
- Composite of cardiac death or heart failure hospitalization (secondary outcome) — Kaplan-Meier-estimated 5-year rate of the composite outcome
- 33.9%
Predictive performance of LARS for the composite outcome
- C-index
- 0.586 [95% CI, 0.541-0.632]
- highest among cardiac remodeling parameters analyzed
Original publication
Left Atrial Strain Predicts Cardiac Outcomes in Moderate Aortic Stenosis. Circ Cardiovasc Imaging. Published 20 February 2026. doi:10.1161/circimaging.125.018451
Summarised from the published abstract; every number is checked against it