Impact of cholesterol on proinflammatory monocyte production by the bone marrow
Authors' conclusion
Collectively, these data highlight that LDL-C impacts haematopoiesis, promoting both the number and the proinflammatory activation of circulating monocytes.
Study context
- Population
- Individuals of the EPIC-Norfolk prospective population study; patients with familial hypercholesterolaemia (FH) and healthy normocholesterolaemic controlsEPIC-Norfolk
- Participants
- 12,304 individuals
- Comparison
- Untreated FH patients vs healthy normocholesterolaemic controls; FH before vs after cholesterol-lowering treatment
- Outcome
- LDL-C association with monocyte production
Main finding
As reported in the abstract
Low-density lipoprotein cholesterol (LDL-C) associated with monocyte percentage
β 0.131
95% CI 0.036–0.225; P = 0.007
LDL-C associated with granulocytes
β −0.876
95% CI −1.046 to −0.705; P < 0.001
Original publication
Impact of cholesterol on proinflammatory monocyte production by the bone marrow. Eur Heart J. Published 3 August 2021. doi:10.
Summarised from the published abstract; every number is checked against it