Impact of coronary artery calcium on mortality and cardiovascular events in metabolic syndrome and diabetes among younger adults
Authors' conclusion
Coronary artery calcium score is independently associated with cardiovascular events and death over nearly 15 years after screening at ages 38-55 years, with a less pronounced impact on CVD and CHD events in the presence of DM.
Study context
- Population
- Adults aged 38–55 years from CARDIA and MESA who completed CT of coronary artery calcium (CAC)CARDIA n = 3047
- Participants
- 5,174 adults
- Comparison
- CAC score by metabolic status
- Diabetes mellitus (DM)n = 461
- Metabolic syndrome (MetS)n = 1,025
- Neithern = 3,688
- Outcome
- Incident CVD, CHD and all-cause death
- Follow-up
- Median 14.2 years
Methodological detailsCARDIA and MESA, multivariable Cox proportional hazards regression
- CARDIA and MESA
- Multivariable Cox proportional hazards regression
Pooled result
As reported in the abstract
Incident CVD per CAC score, by metabolic status
Hazard ratio (95% CI)
DMCAC score
1.22(1.08–1.38)
MetSCAC score
1.18(1.08–1.31)
NeitherCAC score
1.36(1.26–1.46)
DMCAC ≥ 100
2.70(1.25–5.83)
MetSCAC ≥ 100
3.29(1.87–5.79)
NeitherCAC ≥ 100
6.30(4.02–9.86)
Per CAC score, as printed
- Impact of CAC ≥ 100 on cardiovascular disease (CVD) and coronary heart disease (CHD) lower in the presence of DM
- P for interaction < 0.05
Further pooled results
CHD and all-cause death
- Similar associations for CHD and death
Events overall · median follow-up 14.2 years
- Prevalent CAC at baseline
- 1085 (21.0%)
- Deaths
- 256 (5.0%)
- CVD events
- 304 (5.9%)
- CHD events
- 188 (3.6%)
CAC association in DM adjusted for haemoglobin A1c
- Association with all outcomes remained significant
Original publication
Impact of coronary artery calcium on mortality and cardiovascular events in metabolic syndrome and diabetes among younger adults. Eur J Prev Cardiol. Published 7 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →