Impact of high-grade atrioventricular block on outcomes in patients with acute myocardial infarction
Authors' conclusion
High-grade atrioventricular blocks in AMI was associated with high in-hospital mortality, especially in anterior AMI or if occurring during hospitalization. Permanent pacemaker implantation was more frequent in the setting of NSTEMI and among patients developing HAVB during hospital stay.
Study context
- Population
- AMI patients enrolled from January 2005 to September 2024 with available ECG information
- Participants
- 50,279 AMI patients
- Exposure
- Patients presenting with HAVB compared with those without HAVB
- HAVB on admissionn = 747
- HAVB during hospitalizationn = 407
- Outcome
- In-hospital mortality
- Follow-up
- In-hospital
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
HAVB on admissionindependent predictor for in-hospital mortality
1.89(1.42–2.49)
P < 0.001Anterior AMI vs non-anterior AMIstronger impact of HAVB on admission on mortality in anterior compared to non-anterior AMI
3.69(1.99–6.81)
P = 0.02for interactionObservational data: associations, not effects.
Secondary outcomes
| Outcome | HAVB on admission | HAVB during hospitalization | Without HAVB |
|---|---|---|---|
| In-hospital MACCE (cardiogenic shock, stroke, re-infarction or death) | 17% | — not stated in the abstract | 6.0% |
| Mortality, HAVB during hospital stay vs HAVB on admission | 15% | 20% | — not stated in the abstract |
| Permanent pacemaker rate, HAVB during hospital stay vs HAVB on admission | 8% | 25% | — not stated in the abstract |
— not stated in the abstract
- In-hospital MACCE (cardiogenic shock, stroke, re-infarction or death): P < 0.001
- Permanent pacemaker implantation during hospitalization in patients with HAVB on admission: NSTEMI 20%
- Permanent pacemaker implantation during hospitalization in patients with HAVB on admission: STEMI 4.4%
- Permanent pacemaker implantation during hospitalization in patients with HAVB on admission: P < 0.001
- Mortality, HAVB during hospital stay vs HAVB on admission: P = 0.031
- Permanent pacemaker rate, HAVB during hospital stay vs HAVB on admission: P < 0.001
Independent predictors for HAVB on admission
- STEMI and female sex
Original publication
Impact of high-grade atrioventricular block on outcomes in patients with acute myocardial infarction. Eur Heart J Acute Cardiovasc Care. Published 19 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →