Impact of left ventricular function on outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention
Main finding · MACE in CKD patientsResult — go to the resultHazard ratio 1.18 95% CI 0.90–1.54Authors' conclusion
Reduced LVEF may adversely affect outcomes in patients with and without CKD alike.
Study context
- Population
- Patients with chronic kidney disease (CKD) (eGFR <60 mL/min/1.73 m²) undergoing percutaneous coronary intervention (PCI) at a tertiary-care center, 2012–20233,199 (25.9%) with CKD
- Participants
- 12,353 patients
- Exposure
- Reduced left ventricular ejection fraction (LVEF) vs normal LVEF in CKD patients undergoing PCI
- Reduced LVEFn = 751
- Outcome
- MACE:
- All-cause death
- Myocardial infarction (MI)
- Target vessel revascularization
- Follow-up
- 1 year after PCI
Methodological detailssingle-centre
- Single-centre
Main finding
MACE in CKD patients · 1 year
Hazard ratio
1.18
95% CI 0.90–1.54
P = 0.23
Reduced LVEFvs Normal LVEF
HR 1.18 (95% CI 0.90–1.54); P = 0.23
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean LVEF in CKD patients
P < 0.001
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause death in CKD patients | 1.85 (1.10–3.10) | P < 0.05 | |
| MI in CKD patients | 1.78 (1.07–2.98) | P < 0.05 | |
| 0.20.5125Hazard ratio (log scale) |
Major adverse cardiovascular events (MACE) and all-cause death in non-CKD patients (subgroup)
- Non-CKD patients with reduced LVEF had increased risk of MACE and all-cause death; no significant interaction between LVEF and CKD
Original publication
Impact of left ventricular function on outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention. Am Heart J. Published 1 July 2025. doi:10.
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