Valvular & structural heart disease
Impact of mitral regurgitation aetiology on the outcomes of transcatheter aortic valve implantation
Authors' conclusion
TAVI reduces MR severity and symptoms in patients with aFMR, vFMR and less-pronounced PMR. The presence of aFMR was associated with the greatest MR severity improvement.
Study context
- Population
- Consecutive patients with at least moderate mitral regurgitation (MR) undergoing transcatheter aortic valve implantation (TAVI), Munich University Hospital, January 2013–December 2020of 3,474 TAVI patients
- Participants
- 631 patients
- Exposure
- MR aetiology: Atrial functional MR (aFMR) vs vFMR vs primary mitral regurgitation (PMR) in patients undergoing TAVI
- aFMRn = 172
- vFMRn = 296
- PMRn = 163
- Outcome
- Mortality, changes in MR severity and NYHA class
- Follow-up
- 3 years
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
MR improvement · follow-up
aFMR vs vFMR: P = 0.03 · aFMR vs PMR: P < 0.001
- Estimated 3-year survival did not differ between aetiologies
- P = 0.57
Observational data: associations, not effects.
Further findings
Mortality with MR persistence at follow-up
| HR (95% CI) | P value | ||
|---|---|---|---|
| MR persistenceMainly driven by PMR subgroup | 1.49 (1.04–2.11) | P = 0.027 | |
| 0.512Hazard ratio (log scale) |
New York Heart Association (NYHA) class
- NYHA class improved significantly in all groups
Baseline MR ≥3+ (subgroup)
- PMR associated with lowest MR improvement, lowest survival and least symptomatic improvement
Procedural characteristics and endpoints
- Comparable between groups
Original publication
Impact of mitral regurgitation aetiology on the outcomes of transcatheter aortic valve implantation. EuroIntervention. Published 21 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →