Valvular & structural heart disease
Interplay of aortic stenosis flow groups and mitral regurgitation aetiology in patients undergoing transcatheter aortic valve replacement
Authors' conclusion
MR aetiology and severity influence outcomes after TAVR depending on AS flow groups.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) (2013–21) across aortic stenosis (AS) flow groups531 (20.0%) with at least moderate mitral regurgitation (MR) (MR ≥ 2+)
- Participants
- 2,658 patients
- Exposure
- Impact of MR aetiology and severity on outcomes across AS flow groups in TAVR patients
- MR2+n = 531
- Outcome
- Fraction of patients with MR ≥ 2+
Main finding
As reported in the abstract
cLFLG-AS
34.2%
Observational data: associations, not effects.
Further findings
| Outcome | Values | HR (CI) | |
|---|---|---|---|
| Mortality by MR severity · 3 yearsMR2+vs MR < 2All patients | 1.62 (1.38–1.90) | ||
| Mortality by MR severity · 3 yearsMR2+vs MR < 2HG-AS | 1.52 (1.16–1.98) | ||
| Mortality by MR severity · 3 yearsMR2+vs MR < 2pLFLG-AS | 1.73 (1.24–2.40) | ||
| Mortality by MR severity · 3 yearsMR2+vs MR < 2cLFLG-AS; no difference | 1.21 (0.93–1.56) | ||
| 0.512Hazard ratio (log scale) |
Mortality with MR improvement
| HR (CI) | ||
|---|---|---|
| MR improvementHG-AS; lower mortality | 0.21 (0.10–0.43) | |
| MR improvementcLFLG-AS; lower mortality | 0.48 (0.29–0.79) | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| MR aetiology by AS subtype | cLFLG-AS vFMR 83.0% · pLFLG-AS aFMR 43% · PMR 45% | ||
| MR improvement after TAVRpLFLG-AS vs HG-AS | HG-AS 67.2% · pLFLG-AS 48.7% | P = 0.03 | |
| Mortality with MR improvementMR improvement · pLFLG-AS; not the case | 1.32 (CI 0.67–2.59) |
Characteristics of MR ≥ 2+ patients
- Male
- 50.1%
- Median age
- 83.1 years
Original publication
Interplay of aortic stenosis flow groups and mitral regurgitation aetiology in patients undergoing transcatheter aortic valve replacement. Eur Heart J Cardiovasc Imaging. Published 29 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →