Impact of Pullback Pressure Gradient on Clinical Outcomes after Percutaneous Coronary Interventions
Primary result · Target vessel failureResult — go to the resultAdjusted hazard ratio 1.97 95% CI 1.24–3.15Authors' conclusion
PPG-predicted post-PCI physiology was associated with target vessel failure at 1 year.
Study context
- Population
- Patients with hemodynamically significant CAD undergoing percutaneous coronary intervention (PCI)
- Participants
- 855 patients890 vessels
- Comparison
- Predicted suboptimal vs optimal post-PCI physiology
- Primary endpoint
- Target vessel failure:
- Cardiac death
- Target-vessel MI
- Ischemia-driven target vessel revascularization
- Follow-up
- 1 year
Methodological detailsmulticentre
- Multicentre
Primary result
Target vessel failure
Adjusted hazard ratio
1.97
95% CI 1.24–3.15
P = 0.004
Suboptimalvs Optimal
adjusted HR 1.97 (95% CI 1.24–3.15); P = 0.004
As reported in the abstract
Further findings
| Outcome | Mean difference |
|---|---|
| Agreement of predicted vs measured post-PCI FFRLimits of agreement −0.10 to 0.10 | 0.001 |
Correlation of predicted vs measured delta fractional flow reserve (FFR)
- R
- 0.92 (95% CI 0.91-0.93); P<0.001
Original publication
Impact of Pullback Pressure Gradient on Clinical Outcomes after Percutaneous Coronary Interventions. Circ Cardiovasc Interv. Published 25 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →