Periprocedural Myocardial Infarction and Clinical Outcomes in Diffuse versus Focal Coronary Artery Disease
Authors' conclusion
PMI occurred more frequently after PCI for vessels with diffuse than focal coronary physiology, particularly phenotypes with higher troponin elevation or angiographic complications. Associations with 1-year TVF were observed only for PMI phenotypes incorporating angiographic complications; however, findings should be interpreted cautiously because TVF events were sparse.
Study context
- Population
- Patients undergoing PCI in the pullback pressure gradient (PPG) Global registry, treated vessels classified as focal or diffuse by pullback pressure gradient (PPG)patients undergoing PCI
- Participants
- 855 patients
- Exposure
- Vessels with focal versus diffuse diseases defined by pullback pressure gradient (PPG)
- Outcome
- target vessel failure (TVF), a composite of cardiac death, spontaneous target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization
- Follow-up
- 1-year
Main finding
As reported in the abstract
Target vessel failure (TVF) occurred within 1 year
17
Observational data: associations, not effects.
Further findings
Fourth UDMI PMI
Troponin elevation ≥70 × URL
PMI with flow-limiting angiographic complications
PMI with ischemic electrocardiographic changes
- Fourth Universal Definition of Myocardial Infarction (UDMI) periprocedural myocardial infarction (PMI): p=0.048
- Troponin elevation ≥70 × URL: p=0.041
- PMI with flow-limiting angiographic complications: p=0.015
- PMI with ischemic electrocardiographic changes: p=1.000
Original publication
Periprocedural Myocardial Infarction and Clinical Outcomes in Diffuse versus Focal Coronary Artery Disease. Am Heart J. Published 29 September 2026. doi:10.
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