Coronary disease & ACSCohort study
Predictors for Vulnerable Plaque in Functionally Significant Lesions
- Prospective cohort study
- multicentre
- 5 countries
Authors' conclusion
Among low-FFR lesions, the presence of vulnerable plaque can be predicted by PPG combined with FFR without additional anatomical or plaque characteristics.
Study context
- Population
- Patients with invasive fractional flow reserve (FFR) ≤0.80 with pullback pressure gradient (PPG) and plaque analysis on coronary CT angiography and optical coherence tomography
- Participants
- 95 patients
- Exposure
- Predictors of vulnerable plaque in functionally significant lesions
- Outcome
- Vulnerable plaque (plaque rupture or thin-cap fibroatheroma on optical coherence tomography)
Main finding
As reported in the abstract
Vulnerable plaque
Each group vs PPG ≤0.65 and FFR >0.70Odds ratio (95% CI)P value
PPG >0.65adjusted for FFR
6.75(2.39–19.1)
P < 0.001FFR ≤0.70adjusted for PPG
4.61(1.66–12.8)
P = 0.003- Vulnerable plaque present
- 53 lesions (55.8%)
- PPG and FFR significant predictors of vulnerable plaque
- P < 0.05 for all
Observational data: associations, not effects.
Original publication
Predictors for Vulnerable Plaque in Functionally Significant Lesions. JACC Cardiovasc Imaging. Published 11 September 2024. doi:10.1016/j.jcmg.2024.07.021
Summarised from the published abstract; every number is checked against it