Valvular & structural heart disease
Impact of Sex on Severity Assessment and Cardiac Remodeling in Primary Mitral Regurgitation
Authors' conclusion
Despite having hallmarks of more advanced valvular heart disease, women with significant primary MR demonstrate lower mitral RegVol and ventricular volumes than men.
Study context
- Population
- Patients with primary mitral regurgitation (MR) due to valve prolapse referred for preoperative assessment, undergoing TTE and cardiac magnetic resonance (CMR)26% women
- Participants
- 420 patients
- Exposure
- Women vs men
- Outcome
- Abnormally increased LV size, NYHA class III/IV, severe LA dilatation, pulmonary hypertension (multiple endpoints)
Main finding
As reported in the abstract
Optimal RegVol cut-off for abnormally increased LV size
| Group | TTE cut-off | CMR cut-off |
|---|---|---|
| Women | 67 ml | 50 ml |
| Men | 77 ml | 65 ml |
TTE cut-off
Women67 ml
Men77 ml
CMR cut-off
Women50 ml
Men65 ml
- MR regurgitant fraction, but not regurgitant volumes (RegVol), associated in women and men with NYHA class III/IV, severe LA dilatation and pulmonary hypertension
- P ≤ 0.024
Observational data: associations, not effects.
Further findings
Baseline characteristics by sex
- Women older, higher NYHA class, larger indexed LA volumes than men
- P ≤ 0.031
- Women had lower MR effective regurgitant orifice area, RegVol and ventricular volumes than men
- P ≤ 0.002
Original publication
Impact of Sex on Severity Assessment and Cardiac Remodeling in Primary Mitral Regurgitation. JACC Adv. Published 4 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →