Valvular & structural heart disease
Prognostic value of aortic valve calcification in non-severe aortic stenosis with preserved ejection fraction
Authors' conclusion
Sub-severe AVC is a robust risk stratification parameter in patients with non-severe AS
Study context
- Population
- Non-severe aortic stenosis (AS) with LVEF ≥ 50%; CT aortic valve calcification (AVC) by Agatston method
- Participants
- 395 participants
- Exposure
- Sub-severe and severe AVC vs low AVC
- Outcome
- All-cause death under medical surveillance
Methodological detailsAVC cut-offs (1185 arbitrary unit (AU) men, 850 AU women) determined by log-rank test
- AVC cut-offs (1185 AU men, 850 AU women) determined by log-rank test
Main finding
As reported in the abstract
Median survival time under medical surveillance (years)
2.1
0.7–4.9
Observational data: associations, not effects.
Further findings
All-cause death, overall survival adjusted for aortic valve intervention (AVI)
- Same mortality risk pattern persisted
Effect of AVI on all-cause death, by AVC group
- AVI protective in sub-severe and severe AVC
- P ≤ 0.01
- AVI not protective in low AVC
- 218 underwent AVI
Original publication
Prognostic value of aortic valve calcification in non-severe aortic stenosis with preserved ejection fraction. Eur Heart J Cardiovasc Imaging. Published 4 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →