Impact of transfusion strategy on platelet aggregation and biomarkers in myocardial infarction patients with anemia
Authors' conclusion
In this study, we found no impact of a liberal vs. a restrictive transfusion strategy on platelet reactivity and biomarkers in MI patients with anemia.
Study context
- Population
- Myocardial infarction (MI) patients with anemia
- Participants
- 100 patients
- Comparison
- Liberal vs restrictive transfusion strategy
- Liberaln = 50
- Restrictiven = 50reference
- Primary endpoint
- Change in VASP-PRI (difference from baseline and post randomization)
Methodological detailsmulticentre, blinded central VASP-PRI measurement
- Multicentre
- Blinded central VASP-PRI measurement
Primary result
As reported in the abstract
Change in VASP-PRI from baseline to post-randomisation
No difference in change of VASP PRI before and after randomisation between randomised groups
difference 1.2% 95% CI (−10.3-12.7%) (95% CI)
Further findings
Change in platelet reactivity unit (PRU) (VerifyNow)
- No difference in change of PRU before and after randomisation between randomised groups
- difference 13.0 95% CI (−21.8-47.8) (95% CI)
VASP PRI and PRU in transfused patients regardless of randomised group (n = 71)
- VASP PRI: similar results
- 1.7%; 95% CI (−9.5-1.7%) (difference; 95% CI)
- PRU: similar results
- 27.0; 95% CI (−45.0-0.0) (difference; 95% CI)
P-selectin, PAI-1, vWF, TNF-α
- No impact of transfusion strategy or transfusion itself on levels
Original publication
Impact of transfusion strategy on platelet aggregation and biomarkers in myocardial infarction patients with anemia. Eur Heart J Cardiovasc Pharmacother. Published 23 August 2023. doi:10.
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