Coronary disease & ACS

Impact of residual angina on long-term clinical outcomes after percutaneous coronary intervention or coronary artery bypass graft for complex coronary artery disease

Eur Heart J Qual Care Clin OutcomesPublished Post hoc analysis of the randomised SYNTAX Extended Survival study

Primary result · All-cause deathResult — go to the resultAdjusted hazard ratio 1.11 95% CI 0.83–1.47

Authors' conclusion

Among patients with LMCAD and/or 3VD, patient-reported RA at 1 year post-revascularization was independently associated with repeat revascularization at 5 years; however, it did not significantly increase 10-year mortality, irrespective of the primary modality of revascularization or severity of RA.

Study context

Population
Patients with left main CAD and/or three-vessel CAD after percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
Participants
1,428 patients
Comparison
Residual angina vs no residual angina at 1 year after PCI or CABG
  • Residual angina (RA)n = 373
Primary endpoint
All-cause death
Follow-up
10 years

Primary result

As reported in the abstract

Adjusted hazard ratio

1.11

95% CI 0.83–1.47

By group

RAvs no-RA
adjusted HR 1.11 (95% CI 0.83–1.47)

Further findings

OutcomeRAno-RAAdjusted HR (95% CI)
Repeat revascularization · 5 years18.311.5%1.54 (1.10–2.15)

Sensitivity analysis using 6-month Seattle Angina Questionnaire angina frequency (SAQ-AF)

Similar findings

Original publication

Impact of residual angina on long-term clinical outcomes after percutaneous coronary intervention or coronary artery bypass graft for complex coronary artery disease. Eur Heart J Qual Care Clin Outcomes. Published 24 August 2022. doi:10.1093/ehjqcco/qcac052

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