Impaired Exercise Capacity and Mortality Risk in Adults With Congenital Heart Disease
Authors' conclusion
Impaired exercise capacity and CHD complexity are independently associated with all-cause mortality in patients with CHD.
Study context
- Population
- Adults (>18 years) with congenital heart disease (CHD) with cycle ergometer exercise testing, national CHD registry44.6% women
- Participants
- 3,721 adults
- Exposure
- Impaired vs preserved exercise capacity
- Outcome
- All-cause mortality
- Follow-up
- Mean 9.4 ± 6.0 years
Methodological detailsnational registry, multivariable Cox regression
- National registry
- Multivariable Cox regression
Main finding
As reported in the abstract
Mortality by exercise capacity (multivariable Cox)
Hazard ratio (95% CI)P value
50-<70 %ECpredmoderately impaired
2.1(1.4–3.2)
P < 0.001<50 %ECpredseverely impaired
3.5(2.1–6.0)
P < 0.001- Deaths
- 214 (5.8%)
- Mean %ECpred
- 77% ± 20%
Observational data: associations, not effects.
Further findings
Mortality by CHD complexity
| HR (95% CI) | P value | ||
|---|---|---|---|
| Moderate complexityMultivariable-adjusted | 1.9 (1.2–3.0) | P = 0.003 | |
| Great complexityMultivariable-adjusted | 2.3 (1.3–4.2) | P = 0.008 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Impaired Exercise Capacity and Mortality Risk in Adults With Congenital Heart Disease. JACC Adv. Published 28 July 2023. doi:10.
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