Heart failure & cardiomyopathies
Implementation of Guideline-Directed Medical Therapy in Patients with Heart Failure with Reduced Ejection Fraction (OpTIMa-HF Registry)
Authors' conclusion
The OPTIMA-HF registry reported that HFrEF fundamental drugs are prescribed in most Italian patients; however, <50% of patients receive optimal combination therapy, and still not a satisfying number of patients receive target doses. Strategies to improve implementation of guideline-directed medical therapy are needed to improve HF prognosis.
Study context
- Population
- Chronic heart failure (HF) outpatients with HF with reduced ejection fraction (HFrEF), consecutive patients seen between January and October 2022 (T0 phase)HF patients enrolled by 29 centres, of which 1390 (65.9%) had HFrEF · HFrEF 1,390
- Participants
- 2,110 outpatients
- Outcome
- Characteristics of HFrEF patients
Methodological detailsT0 phase-retrospective data collection, conducted in HF outpatients' clinics of Italian hospitals and community HF outpatients' services
- T0 phase-retrospective data collection
- Conducted in HF outpatients' clinics of Italian hospitals and community HF outpatients' services
Main finding
As reported in the abstract
Age
69.5 ± 11.9 years
Males
76.2%
Time since HF diagnosis
4.1 years
Median ejection fraction (EF)
33%
Observational data: associations, not effects.
Further findings
Prescription rates among HFrEF patients
- Renin-angiotensin-aldosterone system inhibitor (RAASi)/angiotensin receptor neprilysin inhibitor (ARNI)
- 89.1%
- ARNI
- 72%
- RAASi
- 17.1%
- Beta-blockers
- 95.1%
- Mineralocorticoid receptor antagonists (MRA)
- 75.8%
- SGLT2i
- 63.2%
Untreated patients without contraindications
- A non-negligible number of patients with no contraindications were not treated with each specific drug
Patients taking all four drug classes
- All four drug classes
- 46.9%
Doses
- Still low number of patients on RAASi/ARNI and beta-blockers treated with a dose ≥50% of target doses
Original publication
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