Heart failure & cardiomyopathies
Importance of Non-Cardiovascular Comorbidities in Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Non-cardiovascular comorbidities such as anaemia, diabetes mellitus and kidney or pulmonary disease in addition to advanced age were independent predictors of adverse outcomes in patients with AF and HFpEF.
Study context
- Population
- Patients with Atrial Fibrillation (AF) and HFpEF (Fushimi AF Registry, Kyoto, Japan; validation in Kyoto Congestive Heart Failure Registry)validation cohort N = 878
- Participants
- 755 patients
- Exposure
- Predictors of cardiac death or heart failure (HF) hospitalization
- Outcome
- Composite of:
- Cardiac death
- HF hospitalization
- Follow-up
- Median 4.4 years
Methodological detailscommunity-based registry, external validation cohort
- Community-based registry
- External validation cohort
Main finding
As reported in the abstract
Independent predictors of cardiac death or HF hospitalisation (multivariate Cox regression)
Hazard ratio (95% CI)
Age ≥75 years
1.72(1.26–2.36)
Anaemia
1.83(1.37–2.46)
CKD
1.69(1.27–2.26)
DM
1.55(1.15–2.09)
Chronic obstructive pulmonary disease
1.87(1.08–3.22)
- Cardiac death or HF hospitalisation
- 246 patients (33%)
Observational data: associations, not effects.
Further findings
Validation in Kyoto Congestive Heart Failure Registry
- Results also the case in Kyoto Congestive Heart Failure registry
Score (1 point each: age, anaemia, CKD, DM, COPD; 0-5 points)
- Score stratified incidence of adverse outcomes in both registries
- P < 0.001
- Both log-rank
Original publication
Importance of Non-Cardiovascular Comorbidities in Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 21 September 2024. doi:10.
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