Arrhythmias & electrophysiology
In Vivo Mapping of Human Ventricular Fibrillation in Brugada Syndrome: The Role of Repolarization Heterogeneity
Authors' conclusion
In patients with BrS, repolarization heterogeneity has a critical role in VF.
Study context
- Population
- Patients with Brugada syndrome undergoing RV outflow tract ablation28 ventricular fibrillation (VF) maps analysed
- Participants
- 21 vs 6
- Comparison
- Brugada syndrome (BrS) patients vs controls
- BrSn = 21
- Controlsn = 6reference
- Outcome
- VF mechanism (rotational, focal, irregular) and spatial overlap of repolarization cliffs with initiating rotational VF activity
Main finding
As reported in the abstract
BrS
90.5%
19 of 21
Controls
0
events
Further findings
Abolition of RV outflow tract repolarization cliffs after ablation
- Confirmed in all but 2 patients
- 94.3%
- In 1 patient with recurrence, VF mapped on anterior RV over a cliff not targeted at first ablation
Original publication
In Vivo Mapping of Human Ventricular Fibrillation in Brugada Syndrome: The Role of Repolarization Heterogeneity. Circ Arrhythm Electrophysiol. Published 3 December 2024. doi:10.
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