Incidence and outcomes of cardiovascular implantable electronic device infections in patients with end-stage kidney disease
Authors' conclusion
CIED infections occur frequently in ESKD patients and are associated with a high mortality. Early lead extraction is not performed routinely but is associated with improved survival.
Study context
- Population
- End-stage kidney disease (ESKD) patients with de novo cardiac implantable electronic device (CIED) implantation, United States Renal Data System, 2006–2014
- Participants
- 15,515 patients
- Exposure
- Lead extraction vs no lead extraction in CIED infection
- Outcome
- Incidence of CIED infection
- Follow-up
- Median 1.3 years
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
CIED infection incidence
Incidence of CIED infection
4.8%
Observational data: associations, not effects.
Further findings
3-year mortality and time to mortality · after propensity score matching
Time to mortality Lead extraction 0.6 year · No lead extraction 0.3 year
Independent risk factors for CIED infection
- Defibrillator, aHR
- 1.48
- Higher BMI, aHR
- 1.01
- Younger age, aHR
- 0.96
Lead extraction by 60 days
- Lead extraction performed
- 50.71%
Reimplantation with new CIED after lead extraction
- Reimplantation
- 13.8%
Original publication
Incidence and outcomes of cardiovascular implantable electronic device infections in patients with end-stage kidney disease. Heart Rhythm. Published 12 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it