Arrhythmias & electrophysiology
Outcomes of device extraction in patients with chronic kidney disease on renal replacement therapy and cardiac implantable electronic device infections
Authors' conclusion
In CKD on RRT patients with CIED infection, device extraction is associated with a reduction in all-cause mortality at 1 year.
Study context
- Population
- Adults with chronic kidney disease (CKD) on renal replacement therapy (RRT) and cardiovascular implantable electronic device (CIED) infection (excluding renal transplantation and prosthetic heart valves)matched cohort n = 302
- Participants
- 530 adults
- Exposure
- Device extraction vs no extraction
- Device extractionn = 151
- No-extractionn = 151reference
- Outcome
- Mortality
- Follow-up
- 1 year
Methodological detailspropensity-score matched, TriNetX research network
- Propensity-score matched
- TriNetX research network
Main finding
1-year survival
Hazard ratio
0.696
95% CI 0.489–0.991
P = 0.043
By group
Device extraction vs No-extraction
HR 0.696 (95% CI 0.489–0.991); P = 0.043
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality, sensitivity analysis (Cox proportional hazards adjusted for baseline confounders) · 1 year
- Confirmed survival benefit of extraction, reduced mortality risk: HR
- 0.581 (0.382-0.883) (95% CI)
- P
- P = 0.011
- Sensitivity analysis
Freedom from complications such as pericardial effusion
- Similar between groups
Safety
Freedom from complications (e.g. pericardial effusion)
- Similar between groups
Original publication
Outcomes of device extraction in patients with chronic kidney disease on renal replacement therapy and cardiac implantable electronic device infections. Heart Rhythm. Published 29 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it