Heart failure & cardiomyopathies
Incidence and Predictors of Heart Failure with Improved Ejection Fraction Category in a Heart Failure with Reduced Ejection Fraction (HFrEF) Patient Population
An erratum to this article was published (ESC Heart Fail, Apr 2025 ↗)
Authors' conclusion
In our study, in this HFrEF patient population managed in a heart failure outpatient clinic, the 1 year incidence of HFimpEF was found to be ~20%. The 1 year incidence of HFimpEF decreased in relation to time since diagnosis of HFrEF. The most important predictors of the development of HFimpEF were female sex, non-ischaemic aetiology, narrower QRS width, and smaller diameter of the left ventricle and left atrium.
Study context
- Population
- HFrEF patients managed in a HF outpatient clinic, Hungarian Heart Failure Registry
- Participants
- 833 patients
- Exposure
- Diagnosed within 3 months vs Diagnosed 3 months–1 year vs Diagnosed beyond 1 year
- Outcome
- Incidence and predictors of development of HF with improved EF (HFimpEF)
- Follow-up
- 1 year
Methodological detailsHungarian Heart Failure Registry, univariate and multivariate logistic regression
- Hungarian Heart Failure Registry
- Univariate and multivariate logistic regression
Main finding
As reported in the abstract
HFrEF
19.5%
162 events
Observational data: associations, not effects.
Further findings
Incidence of HFimpEF by time since HFrEF diagnosis · 1 year
Independent predictors of heart failure with improved ejection fraction (HFimpEF) by time since diagnosis (subgroups) · 1 year
| OR (95% CI) | P value | ||
|---|---|---|---|
| Non-ischaemic aetiologyDiagnosed within 3 months | 4.76 (1.83–12.4) | P < 0.01 | |
| QRS widthDiagnosed within 3 months | 0.81 (0.71–0.94) | P < 0.01 | |
| LVEDDDiagnosed 3 months–1 year | 0.54 (0.32–0.90) | P < 0.05 | |
| Left atrial diameter ≤45 mmDiagnosed 3 months–1 year | 5.44 (1.45–20.4) | P < 0.05 | |
| LVEDD < 67 mmDiagnosed beyond 1 year | 2.71 (1.07–6.88) | P < 0.05 | |
| 0.050.21520Odds ratio (log scale) |
Incidence of HFimpEF by time since HFrEF diagnosis · 1 year
- 1-year incidence of HFimpEF decreased with time since HFrEF diagnosis
Original publication
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