Heart failure & cardiomyopathies
Utility of Left and Right Ventricular Strain in Arrhythmogenic Right Ventricular Cardiomyopathy: A Prospective Multicenter Registry
Authors' conclusion
In a prospective, multicenter registry of ARVC, RV strain assessment added diagnostic value to current echocardiographic criteria by identifying patients who are missed by current echocardiographic criteria yet still fulfill the diagnosis of ARVC. LV strain, by contrast, did not add incremental diagnostic value but was prognostic for identification of high-risk patients.
Study context
- Population
- Patients with suspected arrhythmogenic right ventricular cardiomyopathy (ARVC)Right ventricular (RV) strain feasible in 99
- Participants
- 109 patients
- Comparison
- RV and left ventricular (LV) strain echocardiography vs 2010 ARVC Revised Task Force Criteria
- Outcome
- Diagnostic performance (AUC) against 2010 ARVC Revised Task Force Criteria
Methodological detailsprospective, multicentre registry, LV strain feasible in 85/109 (78%)
- Prospective
- Multicentre registry
- LV strain feasible in 85/109 (78%)
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| RV GLS | 0.76 |
| RV free wall strain | 0.77 |
AUC
- Both AUCs significant; difference between RV GLS and RV free wall strain NS
- P < 0.001
Further findings
Abnormal RV strain phenotype in patients not identified by conventional echo criteria but meeting 2010 Task Force Criteria
- Abnormal RV strain phenotype in patients not identified by conventional echo criteria but meeting 2010 Task Force Criteria: of 69; thresholds RV GLS > −17.9%, RV free wall strain > −21.2%
ARVC prevalence by 2010 Task Force Criteria
- All patients
- 91/109 (83%)
- Those with RV strain measurements
- 83/99 (84%)
Prognosis: death, heart transplantation or ventricular arrhythmia, by LV GLS
- LV GLS prognostic for composite end point
- log-rank P=0.04
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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