Heart failure & cardiomyopathies

Left Bundle Branch Area Pacing in Patients With Cardiac Sarcoidosis

JACC Clin ElectrophysiolPublished Retrospective cohort study

Authors' conclusion

LBBAP in CS is feasible and provided stable long-term lead performance in this cohort.

Study context

Population
Patients with cardiac sarcoidosis (Heart Rhythm Society criteria) undergoing left bundle branch area pacing (LBBAP), January 2020 to March 2024
Participants
19 patients
Outcome
Procedural success, lead performance and outcomes of LBBAP
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Baseline paced QRS duration, mean

139 ± 25 milliseconds

Threshold, mean

0.75 ± 0.26 V

R-wave amplitude

15.2 ± 6.3 mV

Impedance

738 ± 208 Ω

Observational data: associations, not effects.

Further findings

Left ventricular ejection fraction (LVEF) in patients with LBBB, QRS >130 ms and LVEF <50% (n = 4)

LVEF improved from baseline to follow-up
27% ± 17% to 50% ± 12% (P = 0.06)

Pacing parameters by septal involvement

No differences in pacing parameters based on septal involvement

Safety

Acute procedural complications

No acute complications

Original publication

Left Bundle Branch Area Pacing in Patients With Cardiac Sarcoidosis. JACC Clin Electrophysiol. Published 20 November 2025. doi:10.1016/j.jacep.2025.09.046

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