Cohort study
Early Outcomes of Adult Heart Transplantation From COVID-19 Infected Donors
- Retrospective cohort study
- registry (United Network for Organ Sharing)
- propensity-matched cohorts
Authors' conclusion
In this early analysis, although HTs from aCOV donors had increased mortality at 6 months and 1 year, HTs from rrCOV donors had survival similar to that seen in recipients of HTs from non-COV donors.
Study context
- Population
- Adult heart transplantation (HT) recipients; donors in the United Network for Organ Sharing, May 2020–June 2022239 adult HTs from COVID-19 donors
- Exposure
- HT from COVID-19 donors vs non-COV donors
- aCOVn = 150
- rrCOVn = 89
- Outcome
- Mortality after HT
- Follow-up
- 6 months and 1 year
Main finding
As reported in the abstract
Mortality
aCOV vs non-COVCox hazard ratio (95% CI)P value
6 months
1.74(1.02–2.96)
P = 0.0431 year
1.98(1.22–3.22)
P = 0.006Observational data: associations, not effects.
Further findings
COVID-19 donors identified
- COVID-19 donors (NAT positive)
- 1,445
- aCOV donors
- 1,017
- rrCOV donors
- 428
- HTs using COVID-19 donors
- 309
- COVID-19 donors used for adult HT vs non-COV: younger, mostly male
- ∼80%
Original publication
Early Outcomes of Adult Heart Transplantation From COVID-19 Infected Donors. J Am Coll Cardiol. Published 17 May 2023. doi:10.1016/j.jacc.2023.04.022
Summarised from the published abstract; every number is checked against it