Pulmonary vascular disease & thromboembolism
Incidence, Management, and Outcomes of Pulmonary Embolism at Tertiary Pediatric Hospitals in the United States
Main findingResult — go to the resultAdjusted percentage −3% 95% CI −5% to 0%Authors' conclusion
Pediatric patients with PE have a high incidence of underlying chronic disease. Anticoagulation alone remains the mainstay of treatment, with thrombolysis and thrombectomy rarely being used.
Study context
- Population
- Children with pulmonary embolism (PE) treated at US pediatric hospitals, 2015–2021
- Participants
- 3,136 children
- Exposure
- Systemic thrombolysis or directed therapy vs anticoagulation alone
- Outcome
- Treatment use and in-hospital mortality
Methodological detailsmulticentre, administrative database (PHIS)
- Multicentre
- Administrative database (PHIS)
Main finding
As reported in the abstract
Adjusted percentage
−3%
95% CI −5% to 0%
By group
- Overall in-hospital mortality
- 7.5%
- Treatment approach did not change over time
- P = 0.98
- ≥1 comorbidity
- 62%
- Congenital heart disease
- 20%
Observational data: associations, not effects.
Further findings
| Outcome | Difference ($) (95% CI) |
|---|---|
| Total cost of hospitalizationSystemic thrombolysis vs Anticoagulation alone | 113,043 ($62,866, $163,219) |
Length of hospital stay
- Did not differ by treatment
Original publication
Incidence, Management, and Outcomes of Pulmonary Embolism at Tertiary Pediatric Hospitals in the United States. JACC Adv. Published 19 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →