Aortic & peripheral vascular disease
Incidence of myocardial infarction, heart failure, and cardiovascular mortality in patients with peripheral artery disease: trends between 1997 and 2016
Authors' conclusion
The incidence of MI (since 2002) and HF in patients with PAD has significantly decreased over time, together with a decline in CV mortality.
Study context
- Population
- Patients aged ≥18 years with first diagnosis of PAD, Denmark, 1997–2016
- Participants
- 131,568 patients
- Outcome
- Age-standardized incidence rates per 1000 person-years and trends of MI, HF and CV mortality
Methodological detailsDanish nationwide registers, Median age 70.67 (IQR 61-78) years; 53.05% males
- Danish nationwide registers
- Median age 70.67 (IQR 61-78) years; 53.05% males
Main finding
As reported in the abstract
Trends in age-standardized incidence rates (IRs) (APC)
Myocardial infarction (MI) annual percentage change (APC) until 2002 (95% CI 3.3-16.1, P-value 0.2)
+ 0.6
MI APC after 2002
−5.0
95% CI 3.7–6.3P < 0.0001
Heart failure (HF) APC
−3.3
95% CI 2.0–4.6P < 0.0001
Cardiovascular (CV) mortality APC
−3.5
95% CI 3.0–4.0P < 0.0001
Observational data: associations, not effects.
Original publication
Incidence of myocardial infarction, heart failure, and cardiovascular mortality in patients with peripheral artery disease: trends between 1997 and 2016. Eur Heart J Qual Care Clin Outcomes. Published 17 May 2022. doi:10.
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