Valvular & structural heart disease
Incidence, source, and prognostic impact of major bleeding across the spectrum of aortic stenosis
Main finding · Major bleedingResult — go to the resultHazard ratio 3.59 95% CI 1.56–8.29Authors' conclusion
In AS patients, major bleeding is rare but a strong independent predictor of death. AS severity is a determinant of bleeding events.
Study context
- Population
- Outpatients with variable degree of aortic stenosis (AS) severity, May 2016–December 2017
- Participants
- 2,830 outpatients
- Exposure
- Severe AS vs mild AS
- Outcome
- Major bleeding (BARC type ≥3): incidence, source, determinants, prognostic impact
- Follow-up
- Median 2.1 years (IQR 1.4-2.7)
Methodological detailsconsecutive outpatients, competing-risk analysis (death), censored at aortic valve replacement
- Consecutive outpatients
- Competing-risk analysis (death)
- Censored at aortic valve replacement
Main finding
Major bleeding · median follow-up 2.1 years
Hazard ratio
3.59
95% CI 1.56–8.29
P = 0.003
Severe ASvs Mild AS
HR 3.59 (95% CI 1.56–8.29); P = 0.003
As reported in the abstract
- Major bleeding events
- 46
- Incidence of major bleeding
- 0.7%/year
- Gastrointestinal source
- 50%
- Intracranial source
- 30.4%
- AS severity associated with major bleeding
- P = 0.041
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality associated with major bleedingMajor bleedingvs No major bleeding | 5.93 (3.64–9.65) | P < 0.001 | |
| 0.10.31310Hazard ratio (log scale) |
Bleeding risk with severe AS by OAC use
- Increased bleeding risk with severe AS significantly exacerbated in patients using OAC
Original publication
Incidence, source, and prognostic impact of major bleeding across the spectrum of aortic stenosis. Am Heart J. Published 24 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →