Increase in Oral Streptococcal Endocarditis Among Moderate-Risk Patients: Impact of Guideline Changes on Endocarditis Prevention
Main finding · Oral streptococcal IE, moderate-risk patientsResult — go to the resultOdds ratio 2.59 95% CI 1.16–5.81Authors' conclusion
Oral streptococcal IEs increased in the moderate-risk group of patients after the AP guideline change.
Study context
- Population
- Adult infective endocarditis (IE) patients, University Hospital Zurich, 2000–2022, categorised by risk group (ESC and Swiss guidelines)
- Participants
- 752 IE cases
- Exposure
- Period 2 vs period 1
- Period 2n = 589
- Period 1n = 163reference
- Outcome
- Proportion of oral streptococcal IE in moderate-risk patients
Methodological detailssingle-centre
- Single-centre
Main finding
Oral streptococcal IE, moderate-risk patients
Odds ratio
2.59
95% CI 1.16–5.81
By group
Period 2vs Period 1
OR 2.59 (95% CI 1.16–5.81)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Streptococcal IE, low-/unknown-risk patients
Streptococcal IE, no-risk patients
Congenital valve anomalies and oral streptococcal IE (moderate-risk conditions)
| Unadjusted OR (95% CI) | ||
|---|---|---|
| Congenital valve anomalies | 2.52 (1.71–3.71) | |
| 0.20.5125Unadjusted odds ratio (log scale) |
| Outcome | Period 1 | Period 2 |
|---|---|---|
| Streptococcal IE, high-risk patients | — not stated in the abstract | 16% |
— not stated in the abstract
Oral streptococcal IE, all cases
- Oral streptococci caused cases
- 22%
Original publication
Increase in Oral Streptococcal Endocarditis Among Moderate-Risk Patients: Impact of Guideline Changes on Endocarditis Prevention. JACC Adv. Published 6 September 2024. doi:10.
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