Heart failure & cardiomyopathies
Increase of Serum Pancreatic Enzymes During Hospitalization for Acute Heart Failure
An erratum to this article was published (ESC Heart Fail, Apr 2025 ↗)
Authors' conclusion
Patients admitted for AHF exhibited a significant increase in serum values of pancreatic enzymes in the first 72 h, suggesting that an episode of AHF affects the pancreatic tissue. This rise in pancreatic enzymes was associated with HF severity, as reflected by NT-proBNP.
Study context
- Population
- Patients hospitalised for acute HF
- Participants
- 274 patients
- Primary endpoint
- Change in serum amylase and lipase
- Follow-up
- Baseline, 24 and 72 h after hospitalization
Primary result
As reported in the abstract
Serum pancreatic enzymes · first 72 h
- Baseline amylase, median [IQR]
- 47 [33-63] U/L
- Baseline lipase, median [IQR]
- 30 [21-44] U/L
- Both enzymes significantly increased in first 72 h (P for trend)
- <0.001
- Mean change in amylase
- 9 ± 22 U/L
- Mean change in lipase
- 10 ± 22 U/L
Further findings
Association of baseline NT-proBNP with mean change in pancreatic enzymes in 72 h
- Positive correlation with amylase change
- P = 0.02
- Positive correlation with lipase change
- P = 0.006
- Linear regression
Original publication
Increase of Serum Pancreatic Enzymes During Hospitalization for Acute Heart Failure. ESC Heart Fail. Published 26 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →