Heart failure & cardiomyopathies
Implications of Worsening Renal Function Before Hospitalization for Acute Heart Failure
Authors' conclusion
Admission WRF is common in AHF patients and is associated with an increased length of hospitalization, but not adverse in-hospital events, death, or HF readmission. Among those with admission WRF, biomarkers did not risk stratify for adverse events.
Study context
- Population
- Patients hospitalised for acute HF with serum creatinine measured within 3 months before and at admissionAKINESIS subgroup
- Participants
- 406 patients
- Comparison
- Admission worsening renal function (WRF) vs no admission WRF
- Admission WRFn = 106
Primary result
As reported in the abstract
Prevalence of admission WRF
Admission WRF
26%
106
Further findings
Predictors of admission WRF (3 definitions)
- Higher BNP, OR per doubling
- 1.16-1.28 (95% CI 1.00-1.55)
- Lower DBP, OR
- 0.97-0.98 (95% CI 0.96-0.99)
Length of hospitalization
- Alternative WRF definitions: longer hospitalization
- 1.3 to 1.6 days longer (95% CI 1.0-2.2)
- Primary WRF definition: not associated with longer hospitalization
Adverse in-hospital events; death or HF readmission · 30, 90, and 365 days
- WRF across definitions not associated with higher odds of adverse in-hospital events or higher risk of death or HF readmission
Biomarker prognostic ability in patients with WRF
- Biomarkers not prognostic for any outcome
Original publication
Implications of Worsening Renal Function Before Hospitalization for Acute Heart Failure. ESC Heart Fail. Published 3 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →