Increased Body Mass Index and Ventricular Cardiac Magnetic Resonance Characteristics in Adults With Fontan Circulation
Authors' conclusion
Ventricular adaptations in volume and mass incurred by exposure to Fontan circulation are compounded by increased BMI. Obesity may disproportionately affect ventricular volume, mass, and hemodynamics in MLV.
Study context
- Population
- Fontan patients with CMR at ≥16 years of age, Fontan Outcomes Registry using CMR Examinations47% morphologic left ventricle (MLV) and 36% morphologic right ventricle
- Participants
- 983 patients
- Exposure
- Relationship of increased body mass index (BMI) and ventricular characteristics by cardiac magnetic resonance imaging (CMR)
- Outcome
- Overweight or obese
Main finding
As reported in the abstract
- Overweight or obese
- Thirty-nine percent
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| End-diastolic volume and ventricular mass, multivariableObese vs normal weight · end-diastolic volume · multivariable analysis | difference +18.0 mL (95% CI 8.3–27.7) | P < 0.001 |
| End-diastolic volume and ventricular mass, multivariableObese vs normal weight · ventricular mass · multivariable analysis | difference + 19.1 g (95% CI 8.7–29.6) | P < 0.001 |
End-diastolic volume and ventricular mass with increased BMI
- Increased BMI associated with significantly higher end-diastolic volume and ventricular mass
- P < 0.001 for each
Ventricular end-diastolic pressure and Fontan pressure by BMI category
- Median ventricular end-diastolic pressure significantly elevated with increased BMI category
- P = 0.006
- Fontan pressure significantly elevated with increased BMI category
- P = 0.004
Stratified by ventricular morphology
- Similar findings were observed in MLV but not morphologic right ventricle
Original publication
Increased Body Mass Index and Ventricular Cardiac Magnetic Resonance Characteristics in Adults With Fontan Circulation. JACC Adv. Published 25 August 2025. doi:10.
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