Increased prevalence of coronary atherosclerosis in cancer survivors: A retrospective matched cross-sectional study with coronary CT angiography
Main finding · Coronary atherosclerosisResult — go to the resultOdds ratio 1.68 95% CI 1.19–2.36Authors' conclusion
Patients with a history cancer have an increased prevalence of coronary atherosclerosis on CCTA compared to matched patients without cancer. This effect was most pronounced in younger patients aged 30 to 59 years.
Study context
- Population
- Consecutive cancer survivors aged > 30 years who underwent evaluation for stable coronary artery disease with coronary computed tomography angiography (CCTA), and matched controls without oncological history
- Participants
- 312 vs 624
- Exposure
- Cancer survivors compared to matched controls
- Cancer survivorsn = 312
- Control patientsn = 624reference
- Outcome
- Coronary atherosclerosis
Methodological detailspropensity score matching, 1:2 matching
- Propensity score matching
- 1:2 matching
Main finding
As reported in the abstract
Odds ratio
1.68
95% CI 1.19–2.36
P = 0.003
Events by group
Cancer survivorsvs control patients
OR 1.68 (95% CI 1.19–2.36); P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Coronary atherosclerosis, patients aged between 30 and 59 years (subgroup)Aged between 30 and 59 years | 2.21 (1.40–3.49) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Coronary atherosclerosis associated with thoracic radiotherapy, younger population
- Thoracic radiotherapy OR
- 3.29 (95% CI: 1.70-6.38, P < .001)
Baseline characteristics
- Median age at CCTA scan
- 59.2 [50.3-67.5] years
- Female
- 66.0%
Original publication
Increased prevalence of coronary atherosclerosis in cancer survivors: A retrospective matched cross-sectional study with coronary CT angiography. Am Heart J. Published 9 January 2025. doi:10.
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