Arrhythmias & electrophysiology
Incremental value of the signal-averaged ECG for diagnosing arrhythmogenic cardiomyopathy
Authors' conclusion
The SAECG appears to be a surrogate marker for structural abnormalities seen on imaging in those with ARVC.
Study context
- Population
- Probands with arrhythmogenic right ventricular cardiomyopathy (ARVC) and family members, Canadian ARVC Registry196 ARVC, 205 controls
- Participants
- 401 probands
- Comparison
- Signal-averaged electrocardiogram (SAECG) in ARVC of varying severity vs healthy controls
- Controlsn = 205reference
- ARVC mildn = 68
- ARVC severen = 42
- Outcome
- Utility of SAECG in diagnosing ARVC (SAECG abnormalities)
Methodological detailsregistry-based, population representative registry
- Registry-based
- Population representative registry
Performance
As reported in the abstract
SAECG abnormalities
Further findings
Association of SAECG with imaging abnormalities
| OR (95% CI) | ||
|---|---|---|
| SAECGMajor imaging abnormalities | 3.0 (1.3–6.9) | |
| SAECGMinor imaging abnormalities | 3.5 (0.7–16.5) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| SAECG parameters, pathogenic variant carriers with minimal phenotype vs healthy controlsVariant carriers, minimal phenotype vs Controls | filtered QRS duration 111.2 ± 11.2 ms vs 111 ± 7.6 ms | P = 0.93 |
| SAECG parameters, pathogenic variant carriers with minimal phenotype vs healthy controlsVariant carriers, minimal phenotype vs Controls | duration of low amplitude signals < 40 μV 32.3 ± 8.9 ms vs 34.2 ± 7.2 ms | P = 0.32 |
| SAECG parameters, pathogenic variant carriers with minimal phenotype vs healthy controlsVariant carriers, minimal phenotype vs Controls | root mean square of terminal 40 ms of filtered QRS 43.1 ± 25.2 ms vs 38.2 ± 20.2 ms | P = 0.38 |
Association of SAECG with imaging abnormalities
- SAECG not associated with other aspects of phenotype
SAECG parameters, pathogenic variant carriers with minimal phenotype vs healthy controls
- Similar SAECGs to healthy controls
Original publication
Incremental value of the signal-averaged ECG for diagnosing arrhythmogenic cardiomyopathy. Heart Rhythm. Published 14 October 2022. doi:10.
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