Arrhythmias & electrophysiology
Transvenous lead extraction in patients with systemic cardiac device–related infection—Procedural outcome and risk prediction: A GALLERY subgroup analysis
Authors' conclusion
Patients with CDRSI undergoing TLE demonstrate an increased rate of all-cause in-hospital, as well as procedure-related mortality, despite having comparable procedural success rates.
Study context
- Population
- Patients undergoing transvenous lead extraction (TLE) in the GALLERY (GermAn Laser Lead Extraction RegistrY) database722 with cardiac device-related systemic infection (CDRSI) (28.6%)
- Comparison
- CDRSI vs local infection or noninfectious extraction indications
- CDRSIn = 722
- Primary endpoint
- Procedural outcome (complete procedural success, complications, mortality) and its predictors
Primary result
As reported in the abstract
Complete procedural success
P = 0.328
Major complications
P = 0.416
Procedure-related mortality
P = 0.003
All-cause in-hospital mortality
P < 0.001
Further findings
Predictors of procedural complications (multivariate, CDRSI)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Lead age ≥10 years | 3.23 (1.58–6.60) | P = 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Predictors of procedural failure (multivariate, CDRSI)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Lead age ≥10 years | 2.57 (1.03–6.46) | P = 0.04 | |
| 0.10.31310Odds ratio (log scale) |
Predictors of all-cause mortality (multivariate, CDRSI)
| OR (95% CI) | P value | ||
|---|---|---|---|
| LVEF <30% | 1.70 (1.00–2.99) | P = 0.049 | |
| Age ≥75 years | 2.1 (1.27–3.48) | P = 0.004 | |
| CKD | 1.92 (1.17–3.14) | P = 0.01 | |
| Overall procedural complications | 5.15 (2.44–10.84) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Age · CDRSI also had more comorbidities
P < 0.001
Procedure-related mortality
P = 0.003
Safety
Major complications
P = 0.416
Original publication
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