Valvular & structural heart disease
Indirect Mitral Annuloplasty in Patients with Reduced Or Preserved Ejection Fraction: A Real-World, Single-Centre Experience
Authors' conclusion
In this single-centre observational cohort study, CMCS implantation success was high, and associated with low complication rates, improvements in symptoms and echocardiographic variables, and clinically relevant reductions in BNP levels.
Study context
- Population
- Patients with NYHA class II–IV heart failure (HF) and moderate or moderate-to-severe (grade 2+ or 3+) secondary MR (age 83 ± 6 years, 68% female, 72% HFrEF), 2021–2024201 implanted
- Participants
- 204 patients
- Exposure
- Before vs 3 months after Carillon Mitral Contour System (CMCS) implantation
- CMCSn = 204
- Outcome
- Implantation success and 3-month change
- Follow-up
- 3 months
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
3 months
- Successful device implantation
- 201 (98.5%)
- NYHA class improved by ≥1 category
- 94%
- NYHA class I or II
- 98%
- MR decreased by ≥1 grade
- 91%
- Vena contracta width (mm), before to after
- 6.43 ± 0.84 to 3.85 ± 1.19; P < 0.001
- LA area (cm²), before to after
- 44.4 ± 6.0 to 35.4 ± 5.1; P < 0.001
- E/E' ratio, before to after
- 20.1 ± 5.5 to 14.0 ± 3.8; P < 0.001
- Systolic pulmonary artery pressure (mm), before to after
- 44 ± 11 to 35 ± 9; P < 0.001
- Median BNP (pg/mL), before to after
- 2849 to 1390; P < 0.001
Observational data: associations, not effects.
Further findings
Changes by HFrEF vs HFpEF (subgroup) · 3 months
- Changes not different between HFrEF and HFpEF
Safety
- Any procedural complication
- 10.4%
- Circumflex artery compression requiring PCI
- 9.5%
- Coronary sinus injury
- 1.5%
- Procedural mortality
- 0%
Original publication
Indirect Mitral Annuloplasty in Patients with Reduced Or Preserved Ejection Fraction: A Real-World, Single-Centre Experience. ESC Heart Fail. Published 19 November 2025. doi:10.
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