Arrhythmias & electrophysiology
Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC‐atrial fibrillation (AF) risk scores
Authors' conclusion
In patients with AF, the ABC-AF risk scores allow an individual and continuous estimate of the balance between benefits and risks with OAC treatment.
Study context
- Population
- Patients with AF receiving OAC in ARISTOTLE and RE-LY with baseline biomarkers for ABC-AF scores
- Participants
- 23,121 patients
- Comparison
- Observed 1-year risk on OAC vs predicted 1-year risk without OAC
- Primary endpoint
- Net clinical outcome:
- Sum of stroke
- Major bleeding risks
- Follow-up
- 1 year
Primary result
As reported in the abstract
Net clinical outcome by ABC-AF-stroke risk
- ABC-AF-stroke risk >1%/year on OAC (>3% without OAC): OAC consistently provides larger net clinical benefit than no OAC
- ABC-AF-stroke risk <1.0%/year on OAC (<3% without OAC): individualized balancing of risks regarding OAC or no OAC needed
Further findings
Ratio of 1-year major bleeding to stroke/systemic embolism incidence, across ABC-AF risk profiles
- Ratio range
- 1.4 to 10.6
Original publication
Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC‐AF risk scores. Am Heart J. Published 27 March 2023. doi:10.
Summarised from the published abstract; every number is checked against it