Arrhythmias & electrophysiology
Inequities in atrial fibrillation trials: An analysis of participant race, ethnicity, and sex over time
Authors' conclusion
Despite greater awareness, race/ethnicity reporting and representation of non-White groups in AF clinical trials are poor and have not improved significantly over time.
Study context
- Population
- Completed atrial fibrillation (AF) trials registered in ClinicalTrials.gov to December 31, 2023
- Participants
- 1,933,441 participants277 trials
- Outcome
- Participation to prevalence ratio (PPR) of non-White participants (0.8-1.2 suggests proportional representation)
Pooled result
As reported in the abstract
PPR of non-White participants
Non-White participants underrepresented (participation to prevalence ratio (PPR))
0.511
P < .001
Black participants (PPR)
0.263
Hispanic participants (PPR)
0.337
Further pooled results
Proportion of non-White participants
- Median proportion non-White (IQR 6%-27%)
- 12%
Proportion of non-White participants, 2000 vs 2023
- No significant change between 2000 and 2023 (11% vs 9%)
- P = 0.343
Comprehensive race reporting
- Trials reporting comprehensive race information
- 36.1%
Trial characteristics
- Device focused
- 121 (43.7%)
- Industry funded
- 184 (66.4%)
Original publication
Inequities in atrial fibrillation trials: An analysis of participant race, ethnicity, and sex over time. Heart Rhythm. Published 29 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →