Arrhythmias & electrophysiology
Characteristics of contemporary atrial fibrillation clinical trials and their association with industry sponsorship
Authors' conclusion
Industry-funded clinical trials in AF often are larger, more frequently published, multicontinental, and product-focused. Industry funding was found to be associated with significant differences in study enrollment and publication metrics.
Study context
- Population
- Completed atrial fibrillation (AF) clinical trials registered in ClinicalTrials.gov from conception to October 31, 2023clinical trials
- Participants
- 253 trials
- Exposure
- Industry-funded vs nonindustry-funded AF clinical trials
- Industry-fundedn = 171
- Outcome
- Trial characteristics (size, publication, intervention focus, recruitment location, impact factor) by funding source
Methodological detailssystematic assessment of ClinicalTrials.gov registry, Wilcoxon rank-sum test (continuous) and Fisher exact test (categorical)
- Systematic assessment of ClinicalTrials.gov registry
- Wilcoxon rank-sum test (continuous) and Fisher exact test (categorical)
Main finding
As reported in the abstract
Trial characteristics by funding source
Publication rate
P = 0.04
Product-focused
P < 0.001
Multicontinental recruitment
P < 0.001
| Outcome | Industry-funded | Nonindustry-funded | P value |
|---|---|---|---|
| Median patients enrolled | 172 | 80 | P < 0.001 |
| Median impact factor | 7.7 | 7.7 | P = 0.723 |
Observational data: associations, not effects.
Further findings
- Overall proportion of industry-funded trials did not change over time
- P = 1
Original publication
Characteristics of contemporary atrial fibrillation clinical trials and their association with industry sponsorship. Heart Rhythm. Published 6 March 2024. doi:10.
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