Heart failure & cardiomyopathies
Lower limb compression in acute heart failure and predominant tissue congestion: rationale and design of the COMPRESSION-HF trial
Study context
- Population
- Adults with acute decompensated heart failure (ADHF), bilateral leg oedema (grade II or higher of IV), NT-proBNP >1000 pg/ml, and inferior vena cava (IVC) diameter ≤21 mmpatients randomized, recruitment complete
- Participants
- 106 adults
- Planned comparison
- active bilateral lower limb compression vs sham bandaging
- Primary endpoint
- Co-primary: 24-h urinary sodium excretion and change in body weight from baseline
Methodological detailsrationale and design, 1:1 allocation
- Rationale and design
- 1:1 allocation
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Lower limb compression in acute heart failure and predominant tissue congestion: rationale and design of the COMPRESSION-HF trial. ESC Heart Fail. Published 12 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it